Publications

Yousefi S, Chen H, Ingels JF, McCarty MS, Centeno AG, Chintalapudi S, Mulligan MK, Williams PA, John SWM, Jones BW, Jablonski MM, Hollingsworth TJ, Geisert EE, Lu L, Williams RW

Computational approaches towards reducing contamination in single-cell RNA-seq data.
bioRxiv. 2020.

DOI: 10.1101/2020.07.15.205062

Soucy JR, Aguzzi EA, Cho J, Gilhooley MJ, Keuthan C, Luo Z, Monavarfeshani A, Saleem ME, Wang XW, Wohlschlegel J, The RReSTORe Consortium*, Baranov P, Di Polo A, Fortune B, Gokoffski K, Goldberg JL, Guido W, Kolodkin AL, Mason CA, Ou Y, Reh TA, Ross AG, Samuels BC, Welsbie D, Zack DJ, Johnson TV
* as part of The RReSTORe Consortium

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium.
Molecular Neurodegeneration 2023PDF

DOI: 10.1186/s13024-023-00655-y

Canovai A, Tribble JR, Jöe M, Westerlund DY, Amato R, Trounce IA, Dal Monte M, Williams PA

Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection.
Acta Neuropathologica Communications 2023PDF

DOI: 10.1186/s40478-023-01642-6

Tribble JR, Hui F, Quintero H, El Hajji S, Bell K, Di Polo A, Williams PA

Neuroprotection in glaucoma: Mechanisms beyond intraocular pressure lowering.
Molecular Aspects of Medicine 2023PDF

DOI: 10.1016/j.mam.2023.101193

Herrspiegel C, Plastino F, Lardner E, Seregard S, Williams PA, André H, Stålhammar G

A serum protein signature at the time of uveal melanoma diagnosis predicts long-term patient survival.
BMC Cancer 2023PDF

DOI: 10.1186/s12885-023-10757-x

Tribble JR, Hagström A, Jusseaume K, Lardner E, Wong RCB, Stålhammar G, Williams PA

NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve.
Acta Neuropathologica Communications 2023PDF

DOI: 10.1186/s40478-023-01513-0

Nieuwenhuis B, Laperrousaz E, Tribble JR, Verhaagen J, Fawcett JW, Martin KR, Williams PA, Osborne A

Improving adeno-associated viral (AAV) vector-mediated transgene expression in retinal ganglion cells: comparison of five promoters.
Gene Therapy 2023PDF

DOI: 10.1038/s41434-022-00380-z

Stålhammar G, Williams PA, Landelius T

The prognostic implication of latitude in uveal melanoma: A nationwide observational cohort study of all patients born in Sweden between 1947 and 1989.
Discover Oncology 2022PDF

DOI: 10.1007/s12672-022-00584-0

Enz TJ, Maloca PM, Tschopp M, Menke MN, Tribble JR, Williams PA, Inglin N, Steitz U, Scholl HPN, Jöe M, Papazoglou A

Volume-rendered optical coherence tomography angiography during ocular interventions: Advocating for noninvasive intraoperative retinal perfusion monitoring.
Journal of Biophotonics 2022PDF

DOI: 10.1002/jbio.202200169

Rutigliani C, Tribble JR, Hagström A, Lardner E, Jóhannesson G, Stålhammar G, Williams PA

Widespread retina and optic nerve neuroinflammation in enucleated eyes from glaucoma patients.
Acta Neuropathologica Communications 2022PDF

DOI: 10.1186/s40478-022-01427-3

Tribble JR, Kastanaki E, Uslular AB, Rutigliani C, Enz TJ, Williams PA

Valproic acid reduces neuroinflammation to provide retinal ganglion cell neuroprotection in the retina axotomy model.
Frontiers in Cell and Developmental Biology 2022PDF

DOI: 10.3389/fcell.2022.903436

Hagström A, Kal Omar R, Williams PA, Stålhammar G

The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature.
BMC Cancer 2022PDF

DOI: 10.1186/s12885-022-09464-w

Mouhammad ZA, Vohra R, Horwitz A, Thein AS, Rovelt J, Cvenkel B, Williams PA, Azuara-Blanco A, Kolko M

Glucagon-like peptide 1 receptor agonists – potential game changers in the treatment of glaucoma?
Frontiers in Neuroscience 2022PDF

DOI: 10.3389/fnins.2022.824054

Enz TJ, Bittner M, Tribble JR, Williams PA, Thiel MA, Schmid MK, Bachmann LM, Bochmann F

Comparative assessment of retinal blood flow velocity changes following brimonidine and brinzolamide administration using retinal function imaging.
TVST 2022.PDF

DOI: 10.1167/tvst.11.2.1

De Moraes CG, John SWM, Williams PA, Blumberg DM, Cioffi GA, Liebmann JM

Nicotinamide and pyruvate for neuroenhancement in open-angle glaucoma: A phase 2 randomized clinical trial.
JAMA Ophthalmology. 2022.PDF

DOI: 10.1001/jamaophthalmol.2021.4576

Enz TJ, Tribble JR, Williams PA

Comparison of glaucoma-relevant transcriptomic datasets identifies novel drug targets for retinal ganglion cell neuroprotection.
Journal of Clinical Medicine. 2021.PDF

DOI: 10.3390/jcm10173938

Petriti B, Williams PA, Lascaratos G, Chau K-Y, Garway-Heath DF

Neuroprotection in glaucoma: NAD+/NADH redox state as a potential biomarker and therapeutic target.
Cells. 2021.PDF

DOI: 10.3390/cells10061402

Tribble JR, Otmani A, Sun S, Ellis S, Cimaglia G, Vohra R, Jӧe M, Lardner E, Venkataraman AP, Domínguez-Vicent A, Kokkali E, Rho S, G Jóhannesson, Burgess RW, Fuerst PG, Brautaset R, Kolko M, Morgan JE, Crowston JG, Votruba M, Williams PA

Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction.
Redox Biology. 2021.PDF

DOI: 10.1016/j.redox.2021.101988

Tribble JR, Hui F, Jöe M, Bell K, Chrysostomou V, Crowston JG, Williams PA

Targeting diet and exercise for neuroprotection and neurorecovery in glaucoma.
Cells. 2021.PDF

DOI: 10.3390/cells10020295

Tribble JR, Kokkali E, Otmani A, Plastino F, Lardner E, Vohra R, Kolko M, Andre H, Morgan JE, Williams PA

When is a control not a control? Reactive microglia occur throughout the control contralateral pathway of retinal ganglion cell projections in experimental glaucoma.
TVST. 2021.PDF

DOI: 10.1167/tvst.10.1.22

Tribble JR, Otmani A, Kokkali E, Lardner E, Morgan JE, Williams PA

Retinal ganglion cell degeneration in a rat magnetic bead model of ocular hypertensive glaucoma.
TVST. 2021.PDF

DOI: 10.1167/tvst.10.1.21

Bevan RJ, Hughes TR, Williams PA, Good MA, Morgan BP, Morgan JE

Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer’s disease.
Acta Neuropathologica Communications. 2020.PDF

DOI: 10.1186/s40478-020-01094-2

Cimaglia G, Votruba M, Morgan JE, André H, Williams PA

Potential therapeutic benefit of NAD+ supplementation for glaucoma and age-related macular degeneration.
Nutrients. 2020.PDF

DOI: 10.3390/nu12092871

Petrova V, Pearson CS, Ching J, Tribble JR, Solano AG, Yang Y, Love FM, Watt RJ, Osborne A, Reid E, Williams PA, Martin KR, Geller HM, Eva R, Fawcett JW

Protrudin functions as a scaffold in the endoplasmic reticulum to support axon regeneration in the adult central nervous system.
Nature Communications. 2020.PDF

DOI: 10.1038/s41467-020-19436-y

Harder JM, Guymer C, Wood JPM, Daskalakis E, Chidlow G, Zhang C, Balasubramanian R, Cardozo BH, Foxworth NE, Deering KE, Ouellette TB, Montgomery C, Wheelock CE, Casson RJ, Williams PA, John SWM

Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin.
PNAS. 2020.PDF

DOI: 10.1073/pnas.2014213117

Harder JM, Williams PA, Braine CE, Yang H, Thomas J, Foxworth NE, John SWM, Howell GR

Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice.
Journal of Neuroinflammation. 2020.PDF

DOI: 10.1186/s12974-020-02011-z

Casson RJ, Chidlow G, Crowston JG, Williams PA, Wood JPM

Retinal energy metabolism in health and glaucoma.
Progress in Retinal and Eye Research. 2020.PDF

DOI: 10.1016/j.preteyeres.2020.100881

Tribble JR, Harder JM, Williams PA, John SWM

Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice.
Molecular Brain. 2020.PDF

DOI: 10.1186/s13041-020-00603-7

Bevan RJ, Williams PA, Waters CT, Thirgood R, Mui A, Seto S, Good MA, Morgan JE, Votruba M, Erchova I

OPA1 deficiency accelerates hippocampal synaptic remodelling and age-related deficits in learning and memory.
Brain Communications. 2020.PDF

DOI: 10.1093/braincomms/fcaa101

Hui F, Tang J, Williams PA, McGuinness MB, Hadoux X, Casson RJ, Coote M, Trounce IA, Martin KR, van Wijngaarden P, Crowston JG

Improvement in inner retinal function in glaucoma in response to nicotinamide (vitamin B3) supplementation: A crossover randomized clinical trial.
Clinical & Experimental Ophthalmology. 2020.PDF

DOI: 10.1111/ceo.13818

Williams PA, Braine CE, Kizhatil K, Foxworth NE, Tolman NG, Harder JM, Scott RA, Sousa GL, Panitch A, Howell GR, John SWM

Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma.
Molecular Neurodegeneration. 2019.PDF

DOI: 10.1186/s13024-018-0303-3

Williams PA, Crowston JG

Targeting Metabolic Vulnerabilities for Neuroprotection in Glaucoma: B3 or not B3? That is the question.
Glaucoma Today. 2019.PDF

DOI: Link

Tribble JR, Vasalauskaite A, Redmond T, Young RD, Hassan S, Fautsch MP, Sengpiel F, Williams PA, Morgan JE

Midget retinal ganglion cell dendritic and mitochondrial degeneration is an early feature of human glaucoma.
Brain Communications. 2019PDF

DOI: 10.1093/braincomms/fcz035

Williams PA, Harder JM, Cardozo BH, Foxworth NE, John SWM

Nicotinamide treatment robustly protects from inherited mouse glaucoma.
Communicative & Integrative Biology. 2018.PDF

DOI: 10.1080/19420889.2017.1356956

Choquet H, Paylakhi S, Kneeland SC, Thai KK, Hoffmann TJ, Yin J, Kvale MN, Banda Y, Tolman NG, Williams PA, Schaefer C, Melles R, Risch N, John SWM, Nair KS, Jorgenson E

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci.
Nature Communications. 2018.PDF

DOI: 10.1038/s41467-018-04555-4

Harder JM, Williams PA, Soto I, Foxworth NE, Fernandes KA, Freeburg NF, Howell GR, Libby R, John SWM

Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice.
Cell Death & Disease. 2018.PDF

DOI: 10.1038/s41419-018-0705-8

Tribble JR, Williams PA, Caterson B, Sengpiel F, Morgan JE

Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma.
Molecular Brain. 2018.PDF

DOI: 10.1186/s13041-018-0412-5

Williams PA, Marsh-Armstrong N, Howell GR

Neuroinflammation in glaucoma: A new opportunity.
Experimental Eye Research. 2017.PDF

DOI: 10.1016/j.exer.2017.02.014

Williams PA, Harder JM, Foxworth NE, Cochran KE, Philip VM, Porciatti V, Smithies O, John SWM

Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice.
Science. 2017.PDF

DOI: 10.1126/science.aal0092

Williams PA, Harder JM, Foxworth NE, Cardozo BH, John SWM

Nicotinamide and WLDS act together to prevent neurodegeneration in glaucoma.
Frontiers in Neuroscience. 2017.PDF

DOI: 10.3389/fnins.2017.00232

Harder JM, Braine CE, Williams PA, Zhu X, MacNicoll KH, Sousa GL, Buchanan RA, Smith RS, Libby RT, Howell GR, John SWM

Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective.
PNAS. 2017.PDF

DOI: 10.1073/pnas.1608769114

Williams PA, Braine CE, Foxworth NE, Cochran KE, John SWM

GlyCAM1 negatively modulates monocyte entry into the optic nerve head and contributes to radiation-based protection in glaucoma.
Journal of Neuroinflammation. 2017.PDF

DOI: 10.1186/s12974-017-0868-8

Williams PA, John SWM

Glaucoma dialogue – 71509. Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice.
International Glaucoma Review. 2017.

DOI: Link

Williams PA, Harder JM, John SWM

Glaucoma as a metabolic optic neuropathy: making the case for nicotinamide treatment in glaucoma.
Journal of Glaucoma. 2017.PDF

DOI: 10.1097/IJG.0000000000000767

Williams PA, Tribble JR, Pepper KW, Cross SD, Morgan BP, Morgan JE, John SWM, Howell GR

Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma.
Molecular Neurodegeneration. 2016.PDF

DOI: 10.1186/s13024-016-0091-6

Lee ST, Williams PA, Braine CE, Lin DT, John SWM, Irazoqui PP

A miniature, fiber-coupled, wireless, deep-brain optogenetic stimulator.
Transactions on Neural Systems and Rehabilitation Engineering. 2015.PDF

DOI: 10.1109/TNSRE.2015.2391282

Fernandes KA, Harder JM, Williams PA, Rausch RL, Kiernan AE, Nair KS, Anderson MG, John SWM, Howell GR, Libby RT

Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.
Experimental Eye Research. 2015.PDF

DOI: 10.1016/j.exer.2015.06.019

Williams PA, Thirgood RA, Littlewood E, Votruba M, Oliphant H, Good MA, Williams J, Morgan JE

Retinal ganglion cell dendritic degeneration in a mouse model of Alzheimer’s disease.
Neurobiology of Aging. 2013.PDF

DOI: 10.1016/j.neurobiolaging.2013.01.006

Williams PA, Howell GR, Barbay JM, Braine CE, Sousa GL, John SWM, Morgan JE

Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma.
PLoS One. 2013.PDF

DOI: 10.1371/journal.pone.0072282

Williams PA, Piechota M, Von Ruhland C, Taylor E, Morgan JE, Votruba M

Opa1 is essential for retinal ganglion cell synaptic architecture and connectivity.
Brain. 2012.PDF

DOI: 10.1093/brain/awr330

Williams PA, Morgan JE, Votruba M.

Mouse models of dominant optic atrophy: What do they tell us about the pathophysiology of visual loss?
Vision Research. 2011.PDF

DOI: 10.1016/j.visres.2010.08.031

Barnard AR, Issa PC, Perganta G, Williams PA, Davies V, Sekaran S, Votruba M, MacLaren RE.

Specific deficits in visual electrophysiology in a mouse model of dominant optic atrophy.
Experimental Eye Research. 2011.PDF

DOI: 10.1016/j.exer.2011.07.004

Williams PA, Morgan JE, Votruba, M.

Opa1 deficiency in a mouse model of dominant optic atrophy leads to retinal ganglion cell dendropathy.
Brain. 2010.PDF

DOI: 10.1093/brain/awq218